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Aprima 30 | Apremilast 30
Aprima (Apremilast) is prescribed for adult patients in the following conditions:
- Active Psoriatic Arthritis
- Moderate to Severe Plaque Psoriasis in individuals eligible for systemic therapy or phototherapy
- Pediatric Use: Not recommended under 18 years of age due to lack of safety and efficacy data
- Pregnancy: Category C – use only if benefits clearly outweigh potential fetal risks
- Lactation: Unknown if excreted in human milk; caution advised while breastfeeding
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✅ Description:
Apremilast is an oral phosphodiesterase-4 (PDE4) inhibitor.
By blocking PDE4, it raises intracellular cAMP levels, leading to a reduction in proinflammatory cytokines such as:
- TNF-α
- IL-2
- Interferon-γ
- Leukotrienes
- Nitric oxide synthase
This helps rebalance the immune system’s inflammatory response by modulating multiple cytokine pathways, rather than targeting a single one.
✔️ Dosage & Administration
Initial Dose Titration (Days 1–5):
| Day | Morning | Evening |
|---|---|---|
| Day 1 | 10 mg | – |
| Day 2 | 10 mg | 10 mg |
| Day 3 | 10 mg | 20 mg |
| Day 4 | 20 mg | 20 mg |
| Day 5 | 20 mg | 30 mg |
Maintenance Dose (from Day 6):
30 mg twice daily, orally
Can be taken with or without food
Renal Impairment:
In severe renal impairment, reduce to 30 mg once daily
Follow morning-only titration, skipping evening doses
✔️ Adverse Effect
- Nausea
- Diarrhea
- Headache
- Vomiting
- Abdominal pain
- URTI
- GERD, dyspepsia
- Cough, fatigue
- Appetite loss
- Rash
- Insomnia
- Hypersensitivity
✔️ Avoid co-administration with strong CYP450 enzyme inducers, such as:
- Rifampin
- Phenobarbital
- Carbamazepine
- Phenytoin
These significantly reduce apremilast efficacy.
✔️ Contraindications
Known allergy or hypersensitivity to Apremilast or any of its inactive ingredients
✔️ Precautions & Warnings
Depression & Mood Changes: Use with caution in patients with a history of depression or suicidal thoughts. Monitor for mood shifts.
Weight Loss: Unintentional weight loss (5–10%) may occur. Monitor body weight during treatment.
Caregivers should report any changes in mood, appetite, or mental health promptly.
✔️ Storage:
Store in a cool, dry place, protected from light and moisture
Keep out of children’s reach
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
